Pre3 Inflam

Adverse effects of glucocorticoids include:
A.  Decreased blood sugar          
B.  Loss of fat tissue in the face and upper back                
C.  Mood changes and mask infections
D. Decreased feeling in the fingers and toes.

The mechanism of action of NSAIDS is to:
A.  Bind reversibly to thromboxane, preventing release of acetylcholine from mast cells.                              
B.  Inhibit the enzyme cyclooxygenase, preventing synthesis of prostaglandin and thromboxane.
C. Block glucocorticoid channels, stimulating the release of interleukin from white blood cells.                     D. Stimulate release of iron stores from lymph cells, causing migration of white blood cells to inflammed tissue.

Azathioprine (Imuran) is used for:
A.  Supressing inflammation in severe rheumatoid arthritis.
B.  Stimulating inflammation to treat migraine headaches.
C.  Preventing inflammation associated with sports injuries.
D.  Preventing viral infections in patients who are immune suppressed.

A relatively common adverse reaction to diphenhydramine (Benadryl) is:
A.  Sedation
B. Infection
C. Gatric bleeding
D. Rash

Drugs that interact with H1 receptors may be useful in:
1. Gastric ulcer prevention
2. Infection
3. Auto-immune disease
4. Hay fever

A non-steroidal antiinflammatory drug with good action to decrease menstral cramping because of its specificity for sites where intrauterine prostaglandins are produced is:
A.  ibuprophen (MOTRIN, ADVIL)
B.  hydroxyzine (VISTARIL)
C.  cyclophosphamide (CYTOXAN)
D.  Acetaminophen (TYLENOL)

An asthmatic patient with a transplanted kidney begins a course of glucocorticoids. Which adverse effect should be watched for?
1.  Wheezing
2.  Rejection of the transplanted kidney
3.  Hypoglycemia (Low blood sugar)
4.  Gastrointestinal bleeding

A third line agent for treating rheumatoid arthritis is:
A.  hydroxychloroquine
B.  ibuprofen
C.  steroids
D.  abatacept

Which of the following would most likely be given to prevent a patient from rejecting an organ transplant?
A.  Cyclophosphamide
B.  Hydroxychloroquine
C.  Tacrolimus
D.  Immunoglobulin

Special considerations for administering glucorticoids include:
A.  A diabetic will likely need more insulin
B.  Synergistic action lowers the dose of antibiotics if needed for infection
C. A child will need a higher dose than an adult does
D.  People using drugs to prevent bone fractures should stop that therapy while on glucocorticoids

Assuming an NSAID has already been tried in rheumatoid arthritis. Which dug would most likely be tried next?
A.  etanercept
B.  abatacept
C.  hydroxychloroquine
D.  aspirin

A transplant patient receiving immunosupression with drugs such as corticosteroids with tacrolimus, mycophenolate or cyclosporine is at greatest risk for which adverse effect?
A. Sedation
B. Infection
C. Blood clots
D. Hypotension