A. liver
B. renal
C. brain
D. fat
Atheletes have been known to abuse steroids for body building purposes. The mechanism behind this is:
A. Glucocorticoids cause protein synthesis in exercising muscles.
B. Glucocorticoids inhibit insulin from carrying glucose into muscle cells.
C. Glucocorticoids stimulate the uptake of proteins from the GI tract.
D. Glucocorticoids are not the type of steroids abused by athletes.
When ASPIRIN is used as an antiplatelet aggregator to prevent heart or brain attacks, the dose prescribed is:
A. 80 mg once each week
B. 80-325 mg each day
C. 650 mg as neeeded for chest pain or headache
D. 2.5-7.5 g/day
In rheumatoid arthritis, valdecoxib (BEXTRA) was preferred over a traditional NSAID such as naproxen (ALEVE), however it isn't used because:
A. COX-2 inhibitors are associated with a high rate of GI bleeding
B. It was pulled from the market because of significant side effects.
C. It is less expensive.
D. It worked for women but was less effective in men.
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A transplant patient receiving
immunosupression with drugs such as corticosteroids with tacrolimus,
mycophenolate or cyclosporine is at greatest risk for which adverse effect?
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B. Infection
C. Blood clots
D. Hypotension
Indications for H1 blockers include all of the following EXCEPT:
A. Asthma
B. Nasal allergies
C. Itching
D. Motion sickness
In the treatment of allergic rhinitis, nasal sprays of fluticasone are preferred over oral pills of prednisone because:
A. the cost is significantly lower
B. risk of addiction is lower
C. absorption is better
D. there are fewer side effects
Naproxen (ALEVE) works by:
A. Stimulating the release of leukotrines from white blood cells.
B. Blocking the enzyme lipo-oxygenase.
C. Inhibiting prostaglandin synthesis.
D. All of the above
A patient with frequent bruising and fat deposits on the cheeks and shoulders, is being evaluated for Cushing's Syndrome. Dexamethasone is given for several days. What would be tested next?
1. Urine and or cortisol levels.
2. Fasting blood sugar.
3. Hemoglobin A1C
4. Platelets and cholesterol.
Glucocorticoid preparations are available by which routes?
A. Oral and intraveneous only
B. Topical and oral only
C. direct injection into a joint or lesion and inhaled only
D. all of the above routes are available
When systemic steroids are given for replacement (as in Addison's disease), doses are generally _____________ than when they are given for inflammation (such as in an acute asthma attack).
A. larger and given for a longer period of time
B. larger and given for a shorter period of time
C. smaller and given for a longer period of time
D. smaller and given for a shorter period of time
Mr. Kim has had a kidney transplant and has been taking cyclosporin. His serum creatinine is going up. What is the best explanation of this?
A. He is having an allergic reaction to the drug.
B. He is having a very common adverse reaction to the drug.
C. He is rejecting his transplanted kidney.
D. Adverse drug reaction and transplant rejection must both be considered.
A patient is to recieve ketorolac (TORADOL) for 3 days after surgery. This drug will act to:
A. Stimulate the release of leukotrines from white blood cells.
B. Block the enzyme lipo-oxygenase.
C. Inhibit prostaglandin synthesis.
D. All of the above
When glucocorticoid drugs have been given systemically in high dose for several weeks or more:
A. The patient will probably have liver failure which will not resolve on discontinuation of the drug.
B. The patient will probably have liver failure which will resolve on discontinuation of the drug.
C. The patient will have a life-time dependency on the drugs.
D. The dose should be tapered off slowly when the patient no longer needs the steroid.
Drugs that interact with H1 receptors may be useful in:
1. Auto-immune disease
2. Gastric ulcer prevention
3. Infection
4. Hay fever
Drugs used to treat allergies often act to block the effect of:
A. epinephrine
B. mineralcorticoids
C. glucocorticoids
D. histamine
If a patient had a tumor that was secreting adrenocorticotropin (ACTH), what would happen if dexamethasone was given for several days?
A. The tumor would decrease secretion of ACTH.
B. Blood levels of the body's natural glucocorticoid, (cortisol) would remain high.
C. The tumor would increase secretion of ACTH.
D. Blood levels of the body's natural glucocorticoid, (cortisol) would drop.
When comparing antihistamines such as the classic diphenhydramine (BENADRYL) to the more recently marketed fexofenadine (ALLEGRA), you would say that fexofenadine is:
A. Less expensive
B. Available by more routes of administration (oral, intravenous, topical)
C. More likely to cause sedation
D. Less likely to cause dry mouth
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