The time between when a drug response
is observable and when there is no longer an observable drug effect
is called the
A. threshold action.
B. elimination threshold
C. duration of action.D.
onset of action.
"Potency"
refers to:
A.
Whether the drug will work.
B.
The dose required to achieve therapeutic effect.
C.
How quickly the drug will work.
D.
The severity of side effects.
A
drug that occupies and "turns on" a receptor is an:
A.
adjuvant.
B.
affinitant.
C.
antagonist.
D.
agonist.
Before
marketing a new drug, the drug company asks the FDA to approve its
choice of:
A.
The trade name.
B.
The generic name.
C.
The chemical name.
D.
The code name.
Adverse
reactions to drugs occur because:
A.
No drug has only one receptor it binds to.
B.
They are too pure.
C.
Metabolizing enzymes systems are poisoned.
D.
Several drugs can bind to the same cellular site.
Which
of the following would be the most appropriate way to measure
efficacy of a drug?
A.
Analyzing chemically the ingredients of the drug for impurities.
B.
Asking clients if their symptoms were relieved after taking the drug.
C.
Observing clients for harmful side effects while being treated with
the drug.
D.
Testing blood samples for concentration of the drug after the drug
has been given.
Once
a drug's peak effect has been reached, further doses of the drug will
increase efficacy.
A.
true
B.
false
Recombinant
technology is allowing us to:
A.
Insert new genes into a patient, whose own genes don't work
well.
B.
Manufacture proteins in yeast cells.
C.
Design a drug that fits better with a receptor.
D.
Fuse medicines so patients have fewer pills to take
Nicotine
induces P-450 enzymes in the liver. An AIDS patient taking a protease
inhibitor drug which is metabolized by thes enzymes would experience
which of the following if they smoked?
A.
Increased distribution of the protease inhibitor
B.
Lower blood levels of the protease inhibitor
C.
Higher blood levels of the protease inhibitor
D.
Decreased elimination of the protease inhibitor
You
have a patient with Parkinson's disease, and you want to get more
dopamine into the brain. Dopamine is a charged molecule. How can you
accomplish this best?
A.
Give a lipid soluble precurser to dopamine which can convert in the
brain.
B.
Give a water soluble preparation of dopamine which will cross the
bloodbrain barrier.
C.
Give lower doses of dopamine to decrease the diffusion gradient into
the brain.
D.
Give higher doses of dopamine to increase the diffusion gradient into
the brain.
This
term refers to how much response there is to a therapeutic dose of a
drug.
A.
peak effect
B.
potency
C.
efficacy
D.
distribution
A
drug that occupies a receptor but does not activate the receptor is
an:
A.
adjuvant.
B.
affinitant.
C.
agonist.
D.
antagonist.
Most
drug work by:
A.
Changing the electrical charge surrounding a cell.
B.
Preventing other chemicals from attaching to plasma proteins.
C.
Being taken up into a metabolic pathway instead of an amino acid.
D.
Binding to a specific receptor on the cell.
Which
of the following recent advances is most likely to influence future
drug development and use?
A.
Our ability to isolate a chemical out of a plant.
B.
Our ability to alter the natural biological rhythm.
C.
The discovery of substances secreted by microbes to kill other
microbes.
D.
Our knowledge of genetic differences between people.
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